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At the beginning of the 20th century, P. Ehrlich proved the possibility of synthesis according to a given plan of drugs capable of affecting pathogens, and laid the foundations for chemotherapy (See Chemotherapy). In 1928 A. Fleming established that one of the types of molds secretes an antibacterial substance - penicillin. In 1939–40, H. Flory and E. Chain developed a method for obtaining persistent penicillin, learned how to concentrate it, and set up production of the drug on an industrial scale, laying the foundation for a new method of fighting microorganisms — antibiotic therapy. In the USSR, domestic penicillin was obtained in 1942 in the laboratory of ZV Ermol'eva (see Ermol'eva); in the same year, GF Gause and others received a new antibiotic, gramicidin. In 1944, Z. Waxman received streptomycin in the USA. Later, many antibiotics were isolated with different spectrum of antimicrobial action.