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At the beginning of the 20th century, P. Ehrlich proved the possibility of synthesis according to a given plan of drugs capable of affecting pathogens, and laid the foundations for chemotherapy (See Chemotherapy). In 1928 A. Fleming established that one of the types of molds secretes an antibacterial substance - penicillin. In 1939–40, H. Flory and E. Chain developed a method for obtaining persistent penicillin, learned how to concentrate it, and set up production of the drug on an industrial scale, laying the foundation for a new method of fighting microorganisms — antibiotic therapy. In the USSR, domestic penicillin was obtained in 1942 in the laboratory of ZV Ermol'eva (see Ermol'eva); in the same year, GF Gause and others received a new antibiotic, gramicidin. In 1944, Z. Waxman received streptomycin in the USA. Later, many antibiotics were isolated with different spectrum of antimicrobial action.

  • MA Skvortsov and others described their morphology
  • The general laws of the evolution of allergic reactions were revealed by NN Sirotinin
  • The doctrine of vitamins (Vitamins) (vitaminology)
  • it was established that they all participate in the function of various enzyme systems
  • which emerged in the 20th century, developed successfully
  • the pathogenesis of many vitamin deficiencies was deciphered and ways to prevent them were found
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John Smith

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Created at the end of the 19th century by S. Brown-Séquard and others, the doctrine of the endocrine glands (see. Internal secretion) has become an independent medical discipline - endocrinology. The discovery of Insulin revolutionized the treatment of diabetes mellitus (See Diabetes Mellitus). An important role in the development of endocrinology and gynecology was played by the discovery of female sex hormones (see. Sex hormones).

The release in 1936 from the adrenal glands of a substance of a hormonal nature, which was later called Cortisone, and the synthesis (1954) of more effective Prednisolone and others led to the therapeutic use of corticosteroids (See Corticosteroids). Modern endocrinology is no longer limited to the study of the pathology of the endocrine glands; Her problems include the issues of hormone therapy for non-endocrine diseases, and hormonal regulation of functions in a healthy and diseased organism. The development of endocrinology and hormone therapy was facilitated by the work of G. Selye, who put forward the theory of stress and general adaptation syndrome (See Adaptation syndrome).

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M. V. Yanovsky, with his doctrine of the "peripheral (arterial) heart", drew attention to the importance of the vascular section of the circulatory system. S. S. Khalatov and N. N. AnIchkov put forward a "cholesterol theory" of the origin of atherosclerosis. Modern cardiology is a complex discipline: its problems are developed not only by therapists, but also by surgeons, physiologists, biochemists, etc.

John Smith (Sydney, Australia)
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